American scientists have discovered the mechanism of post-partum dilated cardiomyopathy - a disease that occurs in late pregnancy or during the first six weeks after birth and leads to heart failure.

The work of MD Zoltan Arany (Zoltan Arany) and his colleagues from Harvard Medical School published in the journal Nature.

Postpartum cardiomyopathy (PPCM, Peripartum cardiomyopathy) occurs in one out of three thousand pregnant women. As a rule, PPCM occurs in women who are not suffering from heart disease before pregnancy. About half of patients with this diagnosis recover spontaneously, the condition of the other women may significantly worsen until death. Arany and colleagues have established the cause and mechanism of PPCM, as well as the proposed method of its treatment.

At later stages of normal pregnancy in a woman produces several substances that inhibit the growth and development of blood vessels. Scientists have determined that in the case of PPCM placenta produces too much sFLT1 - a substance that prevents the growth of blood vessels by inhibiting the activity of vascular endothelial growth factor VEGF, and decreased activity of the genes PGC1-alpha, is responsible for angiogenesis.Prozac toxicity
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